Sr. Scientist, CMC Antibody Development, Biologics

Title of the Job: Sr. Scientist, CMC Antibody Development, Biologics

Location: San Diego, CA

Job Description: Who We Are:At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose – to relieve suffering for people with great needs, but few options.What We Do:Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington’s disease, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit , and follow the company on , and . (*in collaboration with AbbVie)About the Role: Plays a key role in developing our in vitro and in vivo strategies towards target identification and drug discovery, through to clinical candidate selection. May work and be responsible for conceptualization, initiation, and management of gene therapy programs, and support our existing preclinical stage Biologics programs. Works closely with the Research and Development Teams to design and develop drugs utilizing multiple modalities, and train team members to ensure that methods and data analysis are applied appropriately. May collaborate with other partners and internal colleagues in various aspects of Biologic Programs drug discovery and development._Essential Functions:Initiates, directs and executes pre-clinical scientific research and/or development strategies in research and/or developmentDesign and build innovative in vitro & in vivo approaches to screening drug candidates, both internally and through CRO and academic collaborationsUtilize subject-matter expertise and past-experience to influence the direction of research projects including new target due diligenceWork closely with translational biology / biomarker teamsMaintains broad knowledge of state-of-the-art principles and theoriesMakes major contributions to scientific literature and conferencesMay act as spokesperson on corporate research and development and advise top managementMay participate in development of patent applicationsInterfaces with various departments and serves as internal consultantBiologics specific work will include work on Gene Therapy/mAb/peptide projects from inception to IND-enabling studies. Works with internal colleagues and external collaborators across all disciplines of R&D to select targets and develop Biologics products. Works with the R&D team to design and implement a robust strategy for the growth of the Biologics drug development. Design in vitro and in vivo strategies for development of Biologics and conduct and/or manage in vitro and in vivo studies to measure potency and efficacy. Monitors the latest developments in the Biologics Therapy space for opportunities to in-license or acquire technologies. Prepares detailed data reports and present results to peers, colleagues, and collaborators. Presents data as appropriate at scientific meetings at the National and International levelAbility to deliver drug substance to clinical trials and beyond through the transition period from research to development including Cell line development, Upstream development, and Downstream developmentOther duties as assignedKnowledge and Qualifications:BS/BA and 8+ years of experience the biotech/pharmaceutical industry identifying and developing cell-based disease models capable of miniaturization for drug screening purposes. Experience with primary neurons and iPSC-derived neurons, and their use in assay development, is beneficial. Experience assessing the pharmacological efficacy and MOA of small molecule drug candidatesORMS/MA and 6+ years of similar experience noted aboveORPhD and 4+ years of similar experience noted above; may include postdoc experienceAssimilates data and research findings outside of Neurocrine for application to new scientific projectsMaintains broad knowledge of scientific principles and theories and possesses intellectual mastery of one or more scientific areasMay develop an understanding of other areas and related dependenciesAdvanced knowledge and demonstrated ability working with / recommending a variety of laboratory equipment/toolsAbility to work as part of and lead multiple teamsExhibits leadership skill and ability, typically leads lower levels and/or indirect teamsExcellent computer skillsExcellent interpersonal, communications, problem-solving, analytical thinking skillsSees broader picture, impact on multiple programs, teams and/or departmentsAbility to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiencyExcellent project management skillsThorough understanding of organic chemistry and a well-developed understanding of process chemistry as well as current literatureExcellent laboratory and productivity skillsAPI Manufacturing experienceGood understanding of cGMP requirements in APIDemonstration of cross-functional understanding related to drug development#LI-AD1Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description._ The annual base salary we reasonably expect to pay is $106,400.00-$154,325.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

Company Name: Neurocrine Biosciences

Salary: $106400 – 154325 per year

Apply for the job!