Sr. Principal Scientist, Computational Biology

Title of the Job: Sr. Principal Scientist, Computational Biology

Location: San Francisco, CA

Job Description: Career Category ResearchJob DescriptionJoin Amgen’s Mission of Serving PatientsAt Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.Sr. Principal Scientist, Computational BiologyWhat you will doLet’s do this. Let’s change the world. The Computational Biology group in the Center for Technology and Innovation (CfTI) within the Precision Medicine organization at Amgen is looking for a highly motivated Computational Biologist with expertise in translational and reverse-translational computational biology, biomarker development, assay development, ML algorithms & data science, statistical modeling, handling clinical data sets. This is a high-visibility, individual contributor role preferring experience within matrixed environments representing the function and requiring familiarity with multiple therapeutic areas, with a focus on Oncology.In this vital role, the Sr. Principal Scientist will be a leading expert responsible for planning and executing scientific research within their specialty. They analyze data from their studies, contribute to scientific literature, and guide junior scientists. Their work, using advanced technologies and methodologies, helps in the discovery, development, or enhancement of the company’s products.Responsibilities

• Serve as the primary functional intake point for all requests pertaining to reverse translation analysis performance on clinical data; work cross-functionally across multiple computational groups to assure most effective division of work while leveraging strategic group capabilities and delivering fit-for-purpose insights
• Coordinate with the research Precision Medicine team and Discovery Biomarker functions to ensure coverage of their analytical requests from data generated from Amgen clinical trials and publicly available biomarker and omics datasets
• Coordinate with other Computational Biology staff to compile analysis results for Discovery Biomarkers
• Apply computational, biostatistical, machine learning methods and simulations to facilitate high quality reverse translation and further future translation
• Champion and exemplify the application of knowledge graphs and modern AI/ML (including generative and transfer learning techniques and task-specialization of foundational models) to enable the discovery of new targets, PD biomarkers and patient selection signatures from high-content clinical data
• Conduct analysis (hands-on) pertaining to assessment of biochemical coverage, patient stratification, indication selection and exploration of mechanism of action through the application of data science, knowledge discovery, and data mining techniques
• Develop translational informatics analysis workflows in a high-content, multi-omics, multi-modal data domain encompassing genomics, transcriptomics, proteomics, metabolomics, epigenomics and spatial-omics
• Work with biologists, to leverage information on targeted biological pathways along with development of computational algorithms to manage and mine internal and external genomics and other high content databases.
• Represent CfTI in Amgen program/portfolio teams as a biomarker analysis lead.
• Interface cross-functionally with the early development teams, assay laboratories, in-vitro diagnostics teams, and biomarker representatives

What we expect of youWe are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.Basic Qualifications:Doctorate degree and 2 years of scientific experienceOrMaster’s degree and 4 years of scientific experienceOrBachelor’s degree and 6 years of scientific experienceOrAssociate’s degree and 10 years of scientific experienceOrHigh school diploma / GED and 12 years of scientific experiencePreferred Qualifications:

• PhD in Bioinformatics, Mathematics, Computer Science, Computational Biology or Data Science, with a minor or robust background in Biology
• A working knowledge of bioinformatics, applied mathematics and data science to analyze multi-modal, multi-dimensional and large-scale biological data sets such as those from next-generation sequencing DNASeq, RNASeq, proteomics, imaging and spatial-omics assays
• A working knowledge of platforms and readouts utilized for the assessment of clinical biomarkers including but not limited to flow cytometry, IHC, NGS, immunoassays, imaging, proteomics and transcriptional profiling assays
• Expertise and experience translating insights from population-level analyses to clinical trial data
• A good understanding and practical skills in statistics and their use in data analysis for clinical settings
• A working knowledge and experience of Machine Learning and AI technologies—experience applying ML/AI in clinical trial settings is required
• Ability to translate biological and medical questions into analytical models providing actionable results
• Programming experience in R & Python
• Experience in implementing program-based strategies for both pharmacodynamic and patient stratification biomarkers and in explorations of mechanisms of action
• Familiarity with assay development and qualification requirements for clinical trial support
• Ability to work in a highly matrixed environment and drive scientific and technical innovation collaboratively with other members of the group, as well as with Amgen research community
• A strong scientific background with a proven track record of productivity
• Strong written and oral communication skills, project management skills and organizational awareness, self-motivation, independence, and leadership

What you can expect of usAs we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

Apply nowfor a career that defies imaginationObjects in your future are closer than they appear. Join us.careers.amgen.comIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.Application deadlineAmgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.Salary Range 162,830.00 USD – 201,713.00 USD

Company Name: Amgen

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