Principal Scientist, Translational Science Program Lead- Immunology

Title of the Job: Principal Scientist, Translational Science Program Lead- Immunology

Location: Cambridge, MA

Job Description: Johnson and Johnson is recruiting for a Principal Scientist, Translational Sciences (TS), Immunology Translational Sciences and Medicine (TSM) to be located in Spring House, PA or Cambridge, MA.At Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found.As Immunology Leaders, we know immunology is vital to human health. Driven by a steadfast focus on patient unmet needs, we will redefine treatments for immune diseases by delivering groundbreaking therapies and regimens to patients with immune-mediated disease. For more than two decades we have been a world leader in the development of transformational medicines, establishing one of the strongest, first-in-class portfolios and pipelines in the industry, including the first tumor necrosis factor (TNF) inhibitor, and first interleukin (IL)-12 and IL-23 inhibitors. We push the boundaries of science and creativity, applying our deep disease insights, novel pathway science, new technologies, and treatment modalities to restore immune homeostasis.Johnson & Johnson discovers and develops innovative medical solutions to address important unmet medical needs in the following therapeutic areas: immunology, oncology, neuroscience, infectious diseases & vaccines, cardiovascular & metabolism, and pulmonary hypertension. Please visit for more information.Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it. We are guided by our Credo. Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.Translational Sciences and Medicine (TSM) is an integrated group of scientists composed of a Translational Medicine (TM) team which conducts early clinical development and experimental medicine studies, and a Translational Sciences (TS) team which uses human based data and tissues to support the end to end portfolio. Together, the TSM group will provide the key findings/insights on the next wave of novel therapies for these patients. Organizationally, TSM serves as a pivotal link between Discovery Research and the later phase Clinical Development group. TSM provides the vital scientific and clinical expertise to advance an industry-leading pipeline of novel mechanism small molecules and biologic agents to address unmet need in immune-mediated diseases.TS has a broad remit stretching from support of discovery with human data to support target selection, through development of novel decision- making biomarkers for early phase clinical trials, target-centric indication sequencing and prioritization, and biomarker support of regulatory filings. It has expertise in biomarker development, disease biology research and in the application of immunology and data science technologies.This position requires a highly motivated candidate to drive the translational research of innovative therapies across immune-mediated diseases. The Principal Scientist will serve as a TS Program Lead for Immunology preclinical or clinical programs with a focus on rheumatology with responsibility for the development and implementation of high caliber biomarker plans and driving the group’s strategic direction. Activities include partnering with Discovery and clinical teams to mine preclinical, clinical, and molecular data to identify therapeutic targets for key indications, assess scientific rationales for targets and pathways of interests, develop and validate patient stratification hypothesis and biomarker-based endpoints. The candidate will drive data delivery and analyses in support of key program achievements, contribute to the strategic direction of TS, mentor team members, and partner with cross-functional teams to engage in interactions with external experts to advance Immunology portfolio.Responsibilities are as follows:

• Coordinate the design and execution of translational science and biomarker plans integrating both disease and pathway approaches to support portfolio programs
• Drive operational efficiency for translational biomarker implementation, including engagement with external vendors and academic partners
• Contribute to the strategies on molecular understanding of human diseases, patient stratification and biomarker-based endpoint translational strategies
• Lead team members in the communication of study results and applying those results to making strategic decisions
• Represent TS on program teams working closely with key leaders in partner functions to ensure project goals are met
• Engage in the overall department’s strategic direction with special focus on growing the impact of TS approaches in drug discovery and development
• Lead internal and external collaborations to increase team capabilities or address a strategic need
• Take initiative to identify, pilot and internalize emerging technical approaches that may drive increased value for portfolio execution
• Help build an extensive external network of leaders in Immunology to enable strategic partnerships and awareness of advances in translational and biomarker research
• Prepare and/or advise the preparation and review of protocols, clinical study reports and translational science sections of Translational plans, IBs, INDs, abstracts, manuscripts, and technical reports

Qualifications

• PhD or MD/PhD in immunology or a related field with at least 5 years of relevant experience is required, preferably in pharmaceutical or biotechnology sectors
• Training in rheumatology or experience with translational research in rheumatological diseases
• Experience in translational research, including biomarker analysis, patient stratification, and diagnostic approaches, in the industry setting is strongly preferred
• Project leadership experience in a team environment
• Experience gaining biological insights using translational and biomarker high dimensional biological data (e.g., transcriptomics, genomics, proteomics) is preferred
• Strong communication skills and the ability to optimally navigate and prioritize in a dynamic work environment are required
• Willingness and ability to travel (up to ~10%) is required

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.The anticipated base pay range for this position is 113000 to 195500.The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year. Bonuses are awarded at the Company’s discretion on an individual basis.

• Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.
• Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
• This position is eligible to participate in the Company’s long-term incentive program.
• Employees are eligible for the following time off benefits: – Vacation – up to 120 hours per calendar year
• Sick time – up to 40 hours per calendar year; for employees who reside in the State of Washington – up to 56 hours per calendar year
• Holiday pay, including Floating Holidays – up to 13 days per calendar year of Work, Personal and Family Time – up to 40 hours per calendar year

• Additional information can be found through the link below.

The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market.

Company Name: Johnson & Johnson

Salary: $113000 – 195500 per year

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