Principal Scientist, Discovery Protein Analytics, Discovery Biologics

Title of the Job: Principal Scientist, Discovery Protein Analytics, Discovery Biologics

Location: Boston, MA

Job Description: Job DescriptionWe are on a quest for cures and are committed to be the world’s premier, most research-intensive biopharmaceutical company. Our teams combine leading drug discovery capabilities and world-class R&D with the purpose of turning breakthrough science into life-changing medicines.We are seeking an exceptional and experienced scientist in the role of Principal Scientist of Discovery Protein Analytics in the Boston Discovery Biologics group. The Principal Scientist will be responsible for the leading of a team of discovery scientists focused on advanced analytical characterization of protein therapeutics including mass spectrometry (intact, peptide mapping for glycoform and other post-translational modification analyses), liquid chromatography including SEC and HIC, CE-SDS, cIEF, thermal stability techniques, and other analytical approaches to advance discovery programs from hit-to-lead-to-candidate, and they should have demonstrated experience applying fit-for-purpose, high-throughput analytical characterization techniques in the early drug discovery setting. The scientific leader will be responsible for continued expansion of early developability workflows in Boston in collaboration with the broader Discovery Biologics organization and with downstream organizations at our company.In collaboration with project teams and as a member of department working groups, they will drive the advancement of hits and leads through the biologics pipeline. The role is a key interface within the Boston group and the global Discovery Biologics network, as well as with our process development colleagues at the interface of protein therapeutics discovery and development and other drug discovery functions within our company, as well as with external academic and industrial partners.As a people manager, they will invest in the growth and development of current and future staff to create a culture of collaboration and accountability to enable shared success. The leader will work closely with their team members to leverage strengths and identify opportunities to continually expand skillsets, leadership, and enterprise thinking. We recognize that the diversity in our team is our strength, and we are committed to creating an inclusive environment for all employees. Successful candidates must demonstrate inclusive behaviors in working with a diverse group of researchers to drive our core mission.What you will do:Provide scientific leadership to a team of scientists focused on analytical characterization of a wide variety of protein therapeutic molecules to identify strong candidate molecules for developmentDrive optimization and expansion of protein analytics capabilities and workflows, including advancement of automated solutions for characterization workflows for mass spectrometry, chromatography, and other biophysical characterization methodsExecute on early developability workflows to advance complex protein therapeutics beyond traditional mAbs, including alternative non-Ig scaffolds, bi- or multispecifics, fusion proteins, and ADCs, to quickly identify the most promising lead moleculesManage priorities, resources, and investments aligned with the Discovery Biologics strategyLead and participate in cross-functional project teams to deliver impactful protein therapeutics from discovery to developmentFoster a high-performance culture of collaboration, engagement, self-accountability and inclusionStay abreast of external advancements in relevant scientific fieldsPromote the external reputation of our company’s Discovery Biologics departmentWhat you will need to be successful in this role:Qualifications & ExperiencePhD life sciences or related field with 8+ years of applied experience in a biopharmaceutical setting, MS and 10+ years of experience, or BS and 14+ years of experienceExperience in protein analytical characterization in the early drug discovery setting (prior to candidate selection)Required skills:Deep scientific knowledge of the workflows required for the discovery and analysis of protein therapeuticsStrong technical knowledge of in-depth analytical characterization techniques for biologics, including mass spectrometry (intact, peptide mapping for glycoform and other post-translational modification analyses), SEC, HIC, RP, CE-SDS, cIEF, thermal stabilitySignificant project team experience for programs across drug discovery stages, from tool-molecule generation through preclinical development of therapeutic candidatesPrior direct people management of 2+ FTEs, with demonstrated experience in career developmentChampion for diverse and inclusive culturePreferred skills:Strong presentation and publication recordExperience executing early developability assessments of protein therapeuticsIdeal candidate will have experience in protein therapeutics beyond traditional mAbs including alternative non-Ig scaffolds, bi- or multispecifics, fusion proteins, and ADCsPrior program leadership experiencePrior experience working at the discovery-development interface to facilitate the transition of preclinical candidate molecules into downstream process development-related functions and activitiesExperience in lab automation, including automated analytical data acquisition and analysis workflowsExperience in outsourcing and managing external collaborationsYour role at our company is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At our company, we’re inventing for life.We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively for the common good. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.NOTICE FOR INTERNAL APPLICANTSIn accordance with all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.#EligibleforERPCurrent Employees applyCurrent Contingent Workers applyUS and Puerto Rico Residents Only:Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please if you need an accommodation during the application or hiring process.We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.U.S. Hybrid Work ModelEffective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday – Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance OrdinanceLos Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring OrdinanceSearch Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.Employee Status: RegularRelocation: DomesticVISA Sponsorship: YesTravel Requirements: 10%Flexible Work Arrangements: Not ApplicableShift: Not IndicatedValid Driving License: NoHazardous Material(s): OEB4, harsh chemicals, highly potent proteinsJob Posting End Date: 11/8/2024*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Company Name: MSD

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