Postdoctoral Fellow – MALDI-MS Imaging and Spatial Transcriptomics for Drug Discovery (Onsite)

Title of the Job: Postdoctoral Fellow – MALDI-MS Imaging and Spatial Transcriptomics for Drug Discovery (Onsite)

Location: Cambridge, MA

Job Description: Job DescriptionBe a part of the legacy: Postdoctoral Research Fellow ProgramOur Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.We are seeking a passionate experimental or hybrid scientist with expertise in mass spectrometry imaging for tissue profiling to join the Department of Data, A.I, and Genome Sciences (DAGS) at our company’s Research Laboratories in Cambridge, MA. Our group utilizes innovative Spatial Omics approaches (i.e., CosMx, Xenium, Visium, MERSCOPE, Phenocycler Fusion, COMET, MALDI-MS) to impact all stages of the drug development pipeline from pre-clinical to clinical development. DAGS collaborates closely with the discovery therapeutic areas (i.e., oncology, immunology, neuroscience and cardiometabolic disease) and functional areas (i.e., Data Science & Scientific Informatics, Quantitative Bioscience, ChemBio, Analytical R&D) within the Discovery, Preclinical and Translational Medicine (DPTM) organization to leverage these leading edge technologies for novel target and biomarker identification and validation or to better understand therapeutic mechanisms of action for diseases with high unmet need. Successful candidates will be an active participant in the scientific dialogue of the group and will be able to work independently and proactively collaborate with colleagues.The responsibilities of the candidate include but are not limited to:Pioneering experimental capabilities to integrate mass spectrometry imaging with spatial transcriptomics workflows to enable deep molecular interrogation of tissue samples.Designing, preparing and executing experiments utilizing multiple spatial transcriptomics platforms (i.e., MERFISH, Visium, Xenium, CosMx) and MALDI mass spectrometry imaging with intact human and preclinical tissuesAnalyzing tissue sections from patient samples and pre-clinical models to better characterize cellular cross-talk, distribution in disease, and study biological mechanism in relation to efficacy.Handling fresh frozen and FFPE tissue specimens, including sectioning, staining, imaging, and analysisTroubleshooting and optimizing tissue processing, imaging and/or Next Generation Sequencing (NGS) workflows to ensure high level of quality and reliability of generated resultsPerforming analysis of mass spectrometry imaging, digital pathology, and spatial transcriptomics data using advanced software platforms and/or command line tools (e.g. R, Python)Education Minimum Requirement: Ph.D. in in chemistry, biochemistry, biomedical engineering, molecular and cell biology, or related disciplines or will be completing PhD by May 2025.Required skills and experiences:Hands-on expertise in tissue mass spectrometry imaging, with a preference for MALDI-MS imagingFamiliarity with tissue handling and processing, including sectioning, staining, and imagingKeen understanding of experimental design, underlying scientific principles, and the ability to rigorously analyze and document resultsBeing proactive and collaborating closely across multi-disciplinary groups including the therapeutic area groups, the various functions and groups within DAGS, Quantitative Biosciences, Data Science & Scientific Informatics, as well as external collaboratorsStrong communication (oral and written) and collaboration, including an ability to effectively communicate experimental design, results and conclusionsPreferred Experience and SkillsExperience in spatial transcriptomics, in situ hybridization, immunohistochemistry, or other related histology techniquesDemonstrated experience in computational analysis and interpretation of mass spectrometry imaging and spatial transcriptomics datasetsExperience using Linux/Unix OS and high-performance compute (HPC) environments. Familiarity with coding in R and/or PythonDemonstrated expertise in Neuroscience, Oncology and/or Immunology disease areasPublications in high impact journalPostdoctoralOpportunitiesNOTICE FOR INTERNAL APPLICANTSIn accordance with all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.Current Employees applyCurrent Contingent Workers applyUS and Puerto Rico Residents Only:Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please if you need an accommodation during the application or hiring process.We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.U.S. Hybrid Work ModelEffective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday – Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance OrdinanceLos Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring OrdinanceSearch Firm Representatives Please Read Carefully
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Company Name: MSD

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